Moore2004 - Chronic Myeloid Leukemic cells and T-lymphocyte interaction

Moore2004 - Chronic Myeloid Leukemic cells
and T-lymphocytes interaction
A mathematical model for the
interaction of between cancer cells and immune system, involving
CML cancer cells, naive and effector T-lymphocytes.

This model is described in the article:

A mathematical model for
chronic myelogenous leukemia (CML) and T cell interaction.

Moore H, Li NK.
J. Theor. Biol. 2004 Apr; 227(4):
513-523
Abstract:

In this paper, we propose and analyse a mathematical model
for chronic myelogenous leukemia (CML), a cancer of the blood.
We model the interaction between naive T cells, effector T
cells, and CML cancer cells in the body, using a system of
ordinary differential equations which gives rates of change of
the three cell populations. One of the difficulties in modeling
CML is the scarcity of experimental data which can be used to
estimate parameters values. To compensate for the resulting
uncertainties, we use Latin hypercube sampling (LHS) on large
ranges of possible parameter values in our analysis. A major
goal of this work is the determination of parameters which play
a critical role in remission or clearance of the cancer in the
model. Our analysis examines 12 parameters, and identifies two
of these, the growth and death rates of CML, as critical to the
outcome of the system. Our results indicate that the most
promising research avenues for treatments of CML should be
those that affect these two significant parameters (CML growth
and death rates), while altering the other parameters should
have little effect on the outcome.

This model is hosted on
BioModels Database
and identified by:
BIOMD0000000662.
To cite BioModels Database, please use:
Chelliah V et al. BioModels: ten-year
anniversary. Nucl. Acids Res. 2015, 43(Database
issue):D542-8.

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the public domain worldwide. Please refer to
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