E. coli DNA Gyrase B 24 kDa ATPase domain in complex with [3-(3-ethyl-ureido)-5-(pyridin-4-yl)-isoquinolin-8-yl-methyl]-carbamic acid prop-2-ynyl ester

E. coli DNA Gyrase B 24 kDa ATPase domain in complex with [3-(3-ethyl-ureido)-5-(pyridin-4-yl)-isoquinolin-8-yl-methyl]-carbamic acid prop-2-ynyl ester Descriptor: DNA gyrase subunit B, PHOSPHATE ION, prop-2-ynyl ~{N}-[[3-(ethylcarbamoylamino)-5-pyridin-4-yl-isoquinolin-8-yl]methyl]carbamate Authors: Panchaud, P, Bruyere, T, Blumstein, A.-C, Bur, D, Chambovey, A, Ertel, E.A, Gude, M, Hubschwerlen, C, Jacob, L, Kimmerlin, T, Pfeifer, T, Prade, L, Seiler, P, Ritz, D, Rueedi, G. Deposit date: 2016-12-12 Release date: 2017-04-26 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. J. Med. Chem., 60, 2017

大肠杆菌（E. coli）DNA旋转酶B亚基（DNA gyrase subunit B）的24 kDa ATP酶结构域（ATPase domain），与[3-(3-乙基脲基)-5-(吡啶-4-基)-异喹啉-8-基甲基]氨基甲酸丙-2-炔酯形成复合物。
描述项：DNA旋转酶B亚基、磷酸离子、丙-2-炔基 N-[[3-(乙基氨基甲酰氨基)-5-吡啶-4-基-异喹啉-8-基]甲基]氨基甲酸酯
作者：Panchaud P、Bruyere T、Blumstein A.-C、Bur D、Chambovey A、Ertel E.A、Gude M、Hubschwerlen C、Jacob L、Kimmerlin T、Pfeifer T、Prade L、Seiler P、Ritz D、Rueedi G
保藏日期：2016-12-12
发布日期：2017-04-26
最后修改日期：2024-05-08
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.81 Å
引用文献：《异喹啉乙基脲类抗菌剂的发现与优化》，发表于《药物化学杂志》（J. Med. Chem.），2017年，第60卷