SMYD3 promotes aerobic glycolysis in diffuse large B-cell lymphoma via H3K4me3-mediated PKM2 transcription

Genetic abnormalities in histone methyltransferases (HMTs) frequently occur in diffuse large B-cell lymphoma (DLBCL) and are related to its progression. SET and MYND domain containing 3 (SMYD3) is an HMT that is upregulated in various tumors and promotes their malignancy. To further explore the functional role of SMYD3 in DLBCL, RNA-Seq was carried out on total RNA isolated from SMYD3-knockdown or control OCI-LY8 cells. Overall design: Total RNA isolated from stable SMYD3-knockdown OCI-LY8 cells (shSMYD3 #1 and shSMYD3 #2) and LY8-NC cells was used for RNA-Seq to profile differentially expressed mRNA transcripts.