Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-dimethyl methylene triphosphate

Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-dimethyl methylene triphosphate Descriptor: 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(1-methyl-1-phosphonoethyl)phosphoryl]oxy}phosphoryl]guanosine, 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... Authors: Batra, V.K, Upton, J, Kashmerov, B, Beard, W.A, Wilson, S.H, Goodman, M.F, McKenna, C.E. Deposit date: 2009-09-04 Release date: 2010-06-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues. J.Am.Chem.Soc., 132, 2010

DNA聚合酶β（DNA polymerase β）与双脱氧终止引物及2'-脱氧鸟苷5'-β,γ-二甲基亚甲基三磷酸的三元复合物
描述物：2'-脱氧-5'-O-[(S)-羟基{[(S)-羟基(1-甲基-1-膦酰乙基)膦酰]氧基}膦酰]鸟苷，5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'，5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'，……
作者：Batra V.K.、Upton J.、Kashmerov B.、Beard W.A.、Wilson S.H.、Goodman M.F.、McKenna C.E.
存档日期：2009-09-04
发布日期：2010-06-02
最后修改日期：2023-09-06
检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.1埃（Å）
引用文献：卤代β,γ-亚甲基及亚乙基-dGTP-DNA与DNA聚合酶β的三元复合物：氟代亚甲基类似物立体特异性结合的结构证据。《美国化学会志》（J.Am.Chem.Soc.），132卷，2010年