A single amino acid substitution improves the in vivo immunogenicity of the HPV16 oncoprotein E7(11-20) cytotoxic T lymphocyte epitope.
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Immunization with the epitope produced an epitope-specific tetramer response. In further experiments, immunization with an altered peptide ligand (YMLDLQPETV) of the naturally-occurring epitope (YMLDLQPETT) was shown to produce an enhanced number of CTL detected by tetramers specific for YMLDLQPETT
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2005-01-01
