Support for Y-compensation of mother’s curse affecting lifespan in Drosophila melanogaster

Mother’s curse refers to male-biased deleterious mutations that may accumulate on the mitochondria due to its strict maternal inheritance. If these mutations persist, males should ideally compensate through mutations on the Y-chromosome given its strict paternal inheritance. Previous work has addressed this hypothesis by comparing coevolved and non-coevolved Y-mitochondria pairs placed alongside foreign autosomal backgrounds, expecting males with coevolved pairs to exhibit greater fitness due to Y-compensation. To date, no evidence of Y-compensation has been found. Such an experimental design assumes that Y-chromosomes compensate via direct interaction with mitochondria and/or is independent of autosome evolutionary history. If Y-chromosomes instead compensate by modifying autosomal targets, then this design could obscure Y-compensation by disrupting Y-autosome or mitochondria-autosome coadaptation. Here we address whether Y-chromosomes could ameliorate mitochondrial mutations affecting..., , , # Y-compensation

[https://doi.org/10.5061/dryad.59zw3r2ht](https://doi.org/10.5061/dryad.59zw3r2ht)

Data are longevity values for 27 drosophila melanogaster genotypes that vary in the origin of their Y-chromosome, autosomes, and mitochondria. The genetic elements were derived from three stocks from the National Drosophila Species Stock Center (NDSSC) and include Montpellier, France; Cusco, Peru; and Cape Town, South Africa. All possible combinations of the genetic elements were created. 

## Description of the data and file structure

Data files consist of a master data file (titled \"Longevity\") that contains ALL of the data, and 17 other data files that partition the data into subsets to facilitate analysis in R.  While the \"Longevity\" file contains all 5 genotypes, the \"novel\" file contains the YAM and yAM genotypes (represents our novel experimental design) and the \"previous\" file contains the YaM and yam genotypes (represents the previous works experimental design). Each of these ...