Support for Y-compensation of mother’s curse affecting lifespan in Drosophila melanogaster

Mother’s curse refers to male-biased deleterious mutations that may accumulate on the mitochondria due to its strict maternal inheritance. If these mutations persist, males should ideally compensate through mutations on the Y-chromosome given its strict paternal inheritance. Previous work has addressed this hypothesis by comparing coevolved and non-coevolved Y-mitochondria pairs placed alongside foreign autosomal backgrounds, expecting males with coevolved pairs to exhibit greater fitness due to Y-compensation. To date, no evidence of Y-compensation has been found. Such an experimental design assumes that Y-chromosomes compensate via direct interaction with mitochondria and/or is independent of autosome evolutionary history. If Y-chromosomes instead compensate by modifying autosomal targets, then this design could obscure Y-compensation by disrupting Y-autosome or mitochondria-autosome coadaptation. Here we address whether Y-chromosomes could ameliorate mitochondrial mutations affecting..., , , # Y-compensation

[https://doi.org/10.5061/dryad.59zw3r2ht](https://doi.org/10.5061/dryad.59zw3r2ht)

Data are longevity values for 27 drosophila melanogaster genotypes that vary in the origin of their Y-chromosome, autosomes, and mitochondria. The genetic elements were derived from three stocks from the National Drosophila Species Stock Center (NDSSC) and include Montpellier, France; Cusco, Peru; and Cape Town, South Africa. All possible combinations of the genetic elements were created. 

## Description of the data and file structure

Data files consist of a master data file (titled \"Longevity\") that contains ALL of the data, and 17 other data files that partition the data into subsets to facilitate analysis in R.  While the \"Longevity\" file contains all 5 genotypes, the \"novel\" file contains the YAM and yAM genotypes (represents our novel experimental design) and the \"previous\" file contains the YaM and yam genotypes (represents the previous works experimental design). Each of these ...

母系诅咒（Mother's curse）指的是因线粒体严格遵循母系遗传模式，而在线粒体基因组上积累的雄性偏倚有害突变。若此类突变持续存续，理论上雄性可通过Y染色体上的突变实现补偿——鉴于Y染色体严格的父系遗传特性。此前的研究通过对比共进化与非共进化的Y-线粒体组合（搭配外源常染色体背景）验证了这一假说，预期携带共进化组合的雄性可通过Y染色体补偿展现出更高的适合度。截至目前，尚未发现Y染色体补偿的相关证据。此类实验设计假设Y染色体通过与线粒体的直接相互作用完成补偿，且该过程不依赖常染色体的进化历史。若Y染色体实则通过修饰常染色体靶标实现补偿，则该实验设计可能会通过破坏Y染色体-常染色体或线粒体-常染色体的共适应关系，掩盖Y染色体补偿效应。本研究旨在探究Y染色体是否能够缓解影响……
# Y染色体补偿（Y-compensation）
https://doi.org/10.5061/dryad.59zw3r2ht

本数据集包含27种黑腹果蝇（Drosophila melanogaster）基因型的寿命数据，这些基因型的Y染色体、常染色体与线粒体来源各不相同。上述遗传元件均源自美国国家果蝇物种保藏中心（National Drosophila Species Stock Center, NDSSC）的3个种群，分别来自法国蒙彼利埃、秘鲁库斯科以及南非开普敦。研究人员构建了这些遗传元件的所有可能组合。

## 数据与文件结构说明
数据文件包含一个主数据文件（命名为"Longevity"，即寿命），存储了全部数据集；另有17个数据文件将数据划分为子集，以方便在R语言中开展分析。其中"Longevity"文件包含全部5种基因型，"novel"文件包含YAM与yAM基因型（代表本研究的新型实验设计），"previous"文件包含YaM与yam基因型（代表此前研究的实验设计）。上述各文件……