Modeling Genetic Epileptic Encephalopathies using Brain Organoids
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https://www.ncbi.nlm.nih.gov/sra/SRP277498
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资源简介：
We generated cerebral organoids from genetically engineered human embryonic stem cells (hESCs), modeling the devastating WOREE syndrome (DEE28), as a prototype for genetic epileptic encephalopathies (EEs). Transcriptome analysis of mutated organoids compared to the WT revealed molecular changes related to both early infantile EEs and specifically to WOREE syndrome. Overall design: Transcriptome analysis of WWOX-KO cerebral organoids comprared to age- and batch-matched WT organoids from the hESCs line WiBR3. 4 KO samples and 2 WT samples were included in final analysis, after 2 WT samples failed quality control as described in the manuscript.
创建时间：
2021-07-03
