Role of HO-1 in the anti-inflammatory effect of EGCG in CIN.
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EGCG (10mg/kg body wt) was intravenously infused 15min before the establishment of CIN. The HO-1 inhibitor ZnPP (30mg/kg body wt) was injected intraperitoneally 7h before EGCG pretreatment. The rats were sacrificed at 24h after the establishment of CIN. Renal MPO activity (A) and IL-1βlevel (B) were measured. Renal NLRP3 protein expression was detected by immunofluorescence microscopy (red fluorescence, ×400) (C), and semi-quantified by immunoblotting, expressed as the ratio of NLRP3 and GAPDH (D). (n = 5, * P<0.05 vs. vehicle; # P<0.05 vs. CM; & P<0.05 vs. EGCG).
创建时间：
2016-03-16
