An atypical GdpP enzyme linking cyclic nucleotide metabolism to gene regulation in Mycoplasma bovis

To better understand the role of MbovGdpP in cellular processes, the expression profiles of differentially expressed genes between M. bovis wild type strain HB0801 and MbovGdpP knock-out mutant were determined by RNA-sequencing (RNA-seq). Differential gene expression analysis identified up to 161 genes with significant changes in T6.290 (|log2 fold change| > 1.5 and p < 0.05), with 74 mRNA up-regulated and 87 down-regulated. Transcriptomic analyses revealed the biological importance of MbovGdpP. Overall design: Comparative gene expression profiling analysis of RNA-seq data for M. bovis wild type strain HB0801 and MbovGdpP knock-out mutant.