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Genome-wide maps of PARP-1-bound nucleosomes.. Drosophila melanogaster

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA242505
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PARP-1 binds to specific nucleosomes to regulate gene activity. While PARP-1's role in transcription inititaion is known, a surprising finding here was that PARP-1 is highly enriched at exon-intron and intron-exon boundaries, sort of demarcting exons. This indicating a role in alternative splicing. Overall design: ChIP-seq of PARP1-bound nucleosomes as well as MNase-seq of total nucleosome in Drosophila S2 cells
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2014-03-24
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