Supplemental Tables S1 - S7 from Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset

Supplemental Table S1. Small-molecule Informer Set Description of the small-molecule informer set used in the sensitivity profiling experiment, including protein target or activity. Supplemental Table S2.Cancer cell-line panel Description of the cancer cell lines profiled in this experiment; for a clarification of growth media compositions, see Supplemental Table S10. Supplemental Table S3. Area-under-sensitivity-curve values Area-under-sensitivity-curve (AUC) values for each compound-cell line pair using the indices provided in Supplemental Table S1 and Supplemental Table S2. Supplemental Table S4. Compound target annotations. Compound target annotations used for ACME analysis of the compound dendrogram. Supplemental Table S5. Cellular feature annotations Cellular feature annotations used for ACME analysis of the cell-line dendrogram. Supplemental Table S6. Cell-line mutation annotations Mutation annotations of the cancer cell lines used in ACME analysis of the cell-line dendrogram. Supplemental Table S7. ACME results table Results of ACME analysis of sensitivity profiling data.

补充表 S1：小分子信息素集描述，包括蛋白质靶标或活性，用于敏感性分析实验。补充表 S2：癌细胞系面板描述，本实验中分析的癌细胞系概况；关于培养基组成的详细说明，请参阅补充表 S10。补充表 S3：敏感性曲线下面积值表，对于每个化合物-细胞系对，使用补充表 S1 和补充表 S2 中提供的索引计算得到的敏感性曲线下面积（AUC）值。补充表 S4：化合物靶标注释。用于化合物树状图 ACME 分析的化合物靶标注释。补充表 S5：细胞特征注释。用于细胞系树状图 ACME 分析的细胞特征注释。补充表 S6：细胞系突变注释。用于细胞系树状图 ACME 分析的癌细胞系突变注释。补充表 S7：ACME 结果表。敏感性分析数据的 ACME 分析结果。