Meta-GWAS for tinnitus

The dataset comprises summary statistics from the meta-GWAS of 19 studies on tinnitus. The dataset accompanies the following paper: "Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus" (submitted to Am J Hum Genet) Please cite the paper if using this dataset. Phenotype definition was based on self-administered questionnaires regarding tinnitus and ICD-9 & -10 diagnoses of tinnitus. Summary statistics from 19 independent cohorts were analyzed (see manuscript for details) comprizing 888,214 individuals of European descent, including 75,250 tinnitus cases and 812,964 controls. The meta-analysis included 11,950,440 imputed SNPs. Individual GWASs have been QC'd and harmonyzed using EasyQC followed by fixed-effects IVW meta-analysis using GWAMA. UK Biobank data have been used under project #11516 Dataset columns: rs_number, SNP rsID reference_allele, reference (effect allele) other_allele, other allele (non-effect allele) eaf, effect allele frequency (averaged across studies) beta, effect size for meta-analysis se, standard error of beta beta_95L, lower boundary for the 95% confidence interval for beta beta_95U, upper boundary for the 95% confidence interval for beta z, z-statistic for significance of association p-value, p-value for significance of association -log10_p-value, -log10 for p-value q_statistic, Cohrane's Q-statistic for heterogeneity between studies q_p-value, p-value for Q-statistic i2, I2 measure for heteroegeneity between studies n_studies, number of studies for meta-analysis n_samples, total sample size for meta-analysis effects, direction of effects for different studies