CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH Fulacimstat (COMPOUND86)
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CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH Fulacimstat (COMPOUND86) Descriptor: 1-(3-methyl-2-oxidanylidene-1,3-benzoxazol-6-yl)-2,4-bis(oxidanylidene)-3-[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]pyrimidine-5-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chymase, ... Authors: Schaefer, M, Fuerstner, C. Deposit date: 2024-08-01 Release date: 2024-11-27 Last modified: 2025-04-09 Method: X-RAY DIFFRACTION (1.798 Å) Cite: Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution. J.Med.Chem., 68, 2025
人糜蛋白酶（Chymase）与氟司他特（Fulacimstat，化合物86）复合物的晶体结构
相关组分：1-(3-甲基-2-氧代-1,3-苯并恶唑-6-基)-2,4-二氧代-3-[(1R)-4-(三氟甲基)-2,3-二氢-1H-茚-1-基]嘧啶-5-羧酸、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、糜蛋白酶（Chymase）……
作者：Schaefer M、Fuerstner C
提交日期：2024-08-01
发布日期：2024-11-27
最后修改日期：2025-04-09
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.798埃）
引用文献：Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution. *Journal of Medicinal Chemistry*, 2025, 68
创建时间：
2024-08-01
