Effects of a low carbohydrate ketogenic diet on the expression of genes in mouse tissues

Low carbohydrate ketogenic diet (LCKD) has been used for treatment obesity and epilepsy, however, the molecular mechanism of effect of a LCKD (F3666) on tissues has not been fully investigated. In this study, novel molecular targets of LCKD were explored by gene expression profiling in the liver and cerebral cortex of an LCKD-fed mouse model. Total RNA prepared from mouse tissues after 7 weeks LCKD feeding was analyzed by Agilent Gene Expression Microarray. By comparing the results with the data of regular chow (CE-2)-fed mice, significantly altered genes were extracted.