Exploring the role of neutrophils in inflammatory pain hypersensitivity via single-cell transcriptome profiling

Myeloid CD11b+ cells are crucial mediators in post-operative an CFA-induced inflammation, but their role in pain, particularly the role of neutrophils, is still debated. This study employs single-cell RNA sequencing (scRNA-seq) to analyze CD11b+ cell composition in mice after surgery and CFA treatment and investigates the effects and mechanisms of Nicotinamide N-oxide (NAMO) on neutrophils and pain.