Cathepsin K inhibitor
收藏Protein Data Bank Japan2024-10-30 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/4dmx
下载链接
链接失效反馈官方服务：
资源简介：
Cathepsin K inhibitor Descriptor: (1R,2R)-N-(1-cyanocyclopropyl)-2-{[4-(4-fluorophenyl)piperazin-1-yl]carbonyl}cyclohexanecarboxamide, Cathepsin K, GLYCEROL Authors: Dossetter, A.G, Beeley, H, Bowyer, J, Cook, C.R, Crawford, J.J, Finlayson, J.E, Heron, N.M, Heyes, C, Highton, A.J, Hudson, J.A, Kenny, P.W, Martin, S, MacFaul, P.A, McGuire, T.M, Gutierrez, P.M, Morley, A.D, Morris, J.J, Page, K.M, Rosenbrier Ribeiro, L, Sawney, H, Steinbacher, S, Krapp, S, Jestel, A, Smith, C, Vickers, M. Deposit date: 2012-02-08 Release date: 2012-07-11 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis. J.Med.Chem., 55, 2012
组织蛋白酶K（Cathepsin K）抑制剂的描述符：(1R,2R)-N-(1-氰基环丙基)-2-{[4-(4-氟苯基)哌嗪-1-基]羰基}环己甲酰胺；相关样本组分：组织蛋白酶K、甘油；作者：Dossetter, A.G.、Beeley, H.、Bowyer, J.、Cook, C.R.、Crawford, J.J.、Finlayson, J.E.、Heron, N.M.、Heyes, C.、Highton, A.J.、Hudson, J.A.、Kenny, P.W.、Martin, S.、MacFaul, P.A.、McGuire, T.M.、Gutierrez, P.M.、Morley, A.D.、Morris, J.J.、Page, K.M.、Rosenbrier Ribeiro, L.、Sawney, H.、Steinbacher, S.、Krapp, S.、Jestel, A.、Smith, C.、Vickers, M.；提交日期：2012-02-08；发布日期：2012-07-11；最后修改日期：2024-10-30；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.7 Å；引用文献：(1R,2R)-N-(1-氰基环丙基)-2-(6-甲氧基-1,3,4,5-四氢吡啶并[4,3-b]吲哚-2-羰基)环己甲酰胺（AZD4996）：一种用于骨关节炎治疗的强效高选择性组织蛋白酶K抑制剂。《J.Med.Chem.》，55卷，2012年
创建时间：
2012-02-08
