CSF pharmacokinetics-pharmacodynamics of linezolid in critically brain injured patients, with or without central nervous system healthcare-associated infection. The PK-Pop-LCR Study: A Multicenter Pharmacokinetics and Pharmacodynamics Population Study.

Context: Linezolid is an alternative to vancomycin for treating Gram-positive central nervous system (CNS) healthcare-associated infections. The recommended dosing regimen remains debated. PK-Pop-LCR is a prospective population pharmacokinetic-pharmacodynamic study which included brain injured patients with an external ventricular drainage receiving linezolid at different dosing regimens. Objective: In the attached publication, we investigated the cerebrospinal fluid (CSF) penetration of linezolid and we developed a population pharmacokinetic model using plasma and CSF data. Content and scope of the dataset: This dataset contains anonymized individual patient data and the NONMEM control stream used to build the pharmacokinetic model. An important methodological aspect is the hourly sampling of CSF through external ventricular drainage. The model describes linezolid disposition in both plasma and CSF and enables simulations under varying dosing conditions. These materials are intended to support model-informed precision dosing strategies in critically ill patients and to facilitate reproducibility and further research in CNS pharmacokinetics.