Evaluation of the Radioprotective Effect of Famotidine Against Radiotherapy- induced Acute Toxicity in Patients with Prostate Cancer

Interventions: Oral Famotidine 40mg is administrated daily for 2 months twice per day before 2 months Radiotherapy: Once 4 hours before and the other 3 hours before daily Radiotherapy. A Physician determines Bowel & Urinary Toxicities Grade for the patients every week during the treatment by interviewing and blood cell counts are collected biweekly.
Primary outcome(s): Gastrointestinal Acute Toxicity as assessed using the RTOG Grading Criteria[every week during the treatment and one month after end of the treatment];Genitourinary Acute Toxicity as assessed using the RTOG Grading Criteria[every week during the treatment and one month after end of the treatment]
Study Design: Purpose: Prevention; Allocation: Randomised controlled trial; Masking: Blinded (masking used);Assignment: Parallel;Type of endpoint: Efficacy