Transcriptomic profile of liver fibrosis in mice induced by CCl4

This study is aimed to investigate the underlying mechanisms of didymin on anti-hepatic fibrosis. In brief, mice were randomly devided into three groups,including normal, CCl4 and didymin groups. Except the normal group, mice were intra-peritonelly administrated with 20% CCl4 for 10 weeks to induce liver fibrosis; after modeling successfully, mice in didymin group were subsequently intragastrically administrated with didymin for 6 weeks. Finally, the transcriptomic analysis was performed to acquire the differently expressed genes amog the three groups, trying to figure out the potential targets, which regulated by didymin. Mice were randomly devided into three groups, including normal group, CCl4 group (20% CCl4 for 10 weeks, ip) and didymin group (20% CCl4 for 10 weeks, ip + didymin for 6 weeks, ig).