X-ray crystal structure of human TNKS in complex with a small molecule inhibitor

Protein Data Bank Japan2023-12-20 更新2026-03-21 收录

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X-ray crystal structure of human TNKS in complex with a small molecule inhibitor Descriptor: 1,2-ETHANEDIOL, 3-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)-5-methylisoquinolin-1(2H)-one, GLYCEROL, ... Authors: Oliver, A.W. Deposit date: 2014-07-28 Release date: 2015-07-08 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.37 Å) Cite: Design and discovery of 3-aryl-5-substituted-isoquinolin-1- ones as potent and selective tankyrase inhibitors To be published

人类TNKS与小分子抑制剂结合的X射线晶体结构描述成分：1,2-乙二醇（1,2-ETHANEDIOL）、3-(4-{[4-(二甲氨基)哌啶-1-基]甲基}苯基)-5-甲基异喹啉-1(2H)-酮、甘油（GLYCEROL）等。作者：奥利弗（Oliver, A.W.）提交日期：2014-07-28 发布日期：2015-07-08 最后修改日期：2023-12-20 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.37埃（2.37 Å）引用文献：《3-芳基-5-取代异喹啉-1-酮类强效选择性端锚聚合酶抑制剂的设计与发现》（Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent and selective tankyrase inhibitors），待发表

创建时间：

2014-07-28