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Aluminum Chloride-Mediated Acylation of Methylenecyclobutanes. A Facile Synthetic Protocol for the Construction of Substituted Cyclopentenes

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NIAID Data Ecosystem2026-03-06 收录
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Reactions of methylenecyclobutanes (MCBs) with acyl chlorides produce the corresponding substituted cyclopentene derivatives in moderate to high yields via ring enlargement in the presence of aluminum chloride under mild conditions. A plausible mechanism has been proposed on the basis of control and deuterium labeling experiments.

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2016-02-27
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