X-ray structure of mutant 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with fosmidomycin and NADPH

X-ray structure of mutant 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with fosmidomycin and NADPH Descriptor: 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Henriksson, L.M, Unge, T, Jones, T.A, Mowbray, S.L. Deposit date: 2007-01-04 Release date: 2007-05-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structures of Mycobacterium Tuberculosis 1-Deoxy-D- Xylulose-5-Phosphate Reductoisomerase Provide New Insights Into Catalysis. J.Biol.Chem., 282, 2007

结核分枝杆菌（Mycobacterium tuberculosis）来源的突变型1-脱氧-D-木酮糖5-磷酸还原异构酶（1-deoxy-D-xylulose 5-phosphate reductoisomerase，简称DXR，基因标识Rv2870c）与磷酸霉素（fosmidomycin）和二氢烟酰胺腺嘌呤二核苷酸磷酸（NADPH）形成复合物的X射线晶体结构。描述符：1-脱氧-D-木酮糖5-磷酸还原异构酶、3-[甲酰基(羟基)氨基]丙基膦酸、二氢烟酰胺腺嘌呤二核苷酸磷酸。作者：Henriksson L.M.、Unge T.、Jones T.A.、Mowbray S.L. 存储日期：2007-01-04，发布日期：2007-05-08，最后修改日期：2023-12-13。实验方法：X射线衍射（分辨率2.1 Å）。引用文献：《结核分枝杆菌1-脱氧-D-木酮糖-5-磷酸还原异构酶的结构为催化研究提供新见解》，《J.Biol.Chem.》，2007年，第282卷。