The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A with inhibitor 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (F9F) at the alpha-site, Cesium ion at the metal coordination site, and (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine (KOU) at the beta-site

The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A with inhibitor 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (F9F) at the alpha-site, Cesium ion at the metal coordination site, and (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine (KOU) at the beta-site Descriptor: (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine, 1,2-ETHANEDIOL, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... Authors: Hilario, E, Mueller, L.J, Dunn, M.F. Deposit date: 2020-07-16 Release date: 2021-07-21 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.55 Å) Cite: The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A with inhibitor 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (F9F) at the alpha-site, Cesium ion at the metal coordination site, and (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine (KOU) at the beta-site. To be Published

本数据集为鼠伤寒沙门氏菌色氨酸合酶突变体β-S377A的外部醛亚胺晶体结构，其中α位点结合抑制剂2-({[4-(三氟甲氧基)苯基]磺酰基}氨基)乙基二氢磷酸酯（F9F），金属配位位点结合铯离子，β位点结合(E)-N-({3-羟基-2-甲基-5-[(膦酰氧基)甲基]吡啶-4-基}亚甲基)-L-丝氨酸（KOU）。
描述物：(E)-N-({3-羟基-2-甲基-5-[(膦酰氧基)甲基]吡啶-4-基}亚甲基)-L-丝氨酸、1,2-乙二醇、2-({[4-(三氟甲氧基)苯基]磺酰基}氨基)乙基二氢磷酸酯等。
作者：Hilario, E、Mueller, L.J、Dunn, M.F.
提交日期：2020-07-16
发布日期：2021-07-21
最后修改日期：2023-10-18
解析方法：X射线衍射（分辨率1.55埃）
引用内容：鼠伤寒沙门氏菌色氨酸合酶突变体β-S377A的外部醛亚胺晶体结构，该结构中α位点结合抑制剂2-({[4-(三氟甲氧基)苯基]磺酰基}氨基)乙基二氢磷酸酯（F9F），金属配位位点结合铯离子，β位点结合(E)-N-({3-羟基-2-甲基-5-[(膦酰氧基)甲基]吡啶-4-基}亚甲基)-L-丝氨酸（KOU）。待发表。