Mutations identified in katG under fast or slow growth rates including mutations in katG codon Ser315.

Colonies picked from slow growth (Culture INH69.3) and fast growth culture (Culture INH23.3) after 12–13 MGT were subjected to Sanger sequencing and found to contain katG mutations other than those found in katG codon Ser315. These mutants included 65 out of the 77 colonies that were previously found to be WT for the katG codon Ser315 but were mutated elsewhere in the katG gene. The notation used for each mutation is as follows: original nucleotide followed by the nucleotide number and finally the new nucleotide. The corresponding amino acid changes or effects at each position are also indicated. In cases where an amino acid alteration is indicated by an asterisk there was a truncation of the gene. The square brackets indicate that the mutation was found in both growth rates, curly brackets indicate a mutation found only during slow growth and no brackets indicate a mutation only found during fast growth.Mutations identified in katG under fast or slow growth rates including mutations in katG codon Ser315.