Crystal structure of the human vitamin D receptor ligand binding domain complexed with 1alpha,25-Dihydroxy-2alpha-[2-(1H-tetrazole-1-yl)ethyl]vitamin D3

Crystal structure of the human vitamin D receptor ligand binding domain complexed with 1alpha,25-Dihydroxy-2alpha-[2-(1H-tetrazole-1-yl)ethyl]vitamin D3 Descriptor: (1R,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-2-[2-(1,2,3,4-tetrazol-1-yl)ethyl]cyclohexane-1,3-diol, Vitamin D3 receptor Authors: Kakuda, S, Takimoto-Kamimura, M. Deposit date: 2013-01-18 Release date: 2014-01-22 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Synthesis of 2 alpha-heteroarylalkyl active vitamin d3 with therapeutic effect on enhancing bone mineral density in vivo ACS MED.CHEM.LETT., 4, 2013

人维生素D受体配体结合域（ligand binding domain）与1α,25-二羟基-2α-[2-(1H-四唑-1-基)乙基]维生素D3结合的晶体结构。描述符：(1R,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-甲基-1-[(2R)-6-甲基-6-羟基庚-2-基]-2,3,3a,5,6,7-六氢-1H-茚-4-亚基]亚乙基]-4-亚甲基-2-[2-(1,2,3,4-四唑-1-基)乙基]环己烷-1,3-二醇，维生素D3受体。作者：Kakuda S、Takimoto-Kamimura M。提交日期：2013-01-18，发布日期：2014-01-22，最后修改日期：2023-11-08。实验方法：X射线衍射（分辨率2.84埃）。引用文献：《具有体内增强骨密度治疗效果的2α-杂芳基烷基活性维生素D3的合成》，ACS MED.CHEM.LETT.，4卷，2013年。