Senescent fibroblasts and innate immune cell activation might play a role in the pathogenesis of elderly atopic dermatitis

Elderly atopic dermatitis is a subtype of AD defined by age (over 60 years), which has different clinical manifestations and distinct inflammatory patterns from AD in infants, children, and adolescents/adults. However, the molecular characteristics of elderly AD remain to be clarified.We sought to characterize the molecular features of skin lesions and peripheral blood mononuclear cells (PBMCs) in patients with AD across various age groups, focusing on elderly AD.We identified the molecular phenotypes of skin lesions and PBMCs in elderly individuals with AD. Fibroblasts, innate immune cells, and SASP might play important roles in the pathogenesis of elderly AD. Overall design: Skin and PBMCs samples were used for RNA extraction and sequencing. Analysis of differentially expressed genes (DEGs), pathway enrichment, and gene set variation analysis (GSVA) were performed.