Highly Enantioselective Construction of Hajos–Wiechert Ketone Skeletons via an Organocatalytic Vinylogous Michael/Stetter Relay Sequence

A highly enantioselective supramolecular iminium-catalyzed vinylogous Michael addition/Stetter relay sequence has been developed. This transformation provided a series of Hajos–Wiechert-type fused bicyclic diones with three continuous stereogenic centers in good yields with excellent enantioselectivities. The obtained products can be easily transformed into other structures with potential synthetic value.一种高度专一的分子间咪唑催化的烯醇醚化迈克尔加成/斯特特循环序列已被开发。该转化过程生成了一系列含有三个连续手性中心的哈约斯-维希尔特型稠合双环二酮，以良好的产率和优异的构型选择性获得。所得产物可轻易转化为其他具有潜在合成价值的结构。