The fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome

Data from ProteomeXchange, PXD ID: PXD001908. File: Mtl1.Iss10-6F.mzml. From ProteomeXchange: {{i}} Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. However, the mechanism by which they are recognized and targeted to the exosome is not fully understood. Here, we report that the MTREC complex, which has recently been shown to promote degradation of meiotic mRNAs and regulatory ncRNAs, is also the major nuclear exosome targeting complex for CUTs and unspliced pre-mRNAs in Schizosaccharomyces pombe. MTREC complex specifically binds to CUTs, meiotic mRNAs and unspliced pre-mRNA transcripts and targets these RNAs for degradation by the nuclear exosome, while the TRAMP complex has only a minor role in this process ... {{/i}}