Expression data from murine colorectal tumors of mice fed a normal chow diet and a high fat diet

Obesity increases colorectal cancer despite other disturbances. We have used the AOM/DSS protocol to induce colitis-associated cancer in normal chow diet and high fat diet fed animals. Tumors were microdissected and global gene expression was analysed using microarray. Upon weaning animals were either fed a normal chow (NCD) or a high fat diet (HFD) for 14 weeks. Azoxymethane (AOM) (10mg/kg) was injected at week 8 and 4 days later 1.5% dextrane sodium sulphate (DSS) was supplied in the drinking water for 5 days. Mice were sacrificed 62 days after AOM injection and colorectal tumors were microdissected and processed for RNA isolation.