Single-cell transcriptomics identifies synergistic role of leukemic and non-leukemic immune repertoires in CD8+ T-cell Large Granular Lymphocytic Leukemia

Data to reproduce findings in the manuscript "Single-cell transcriptomics identifies synergistic role of leukemic and non-leukemic immune repertoires in CD8+ T-cell Large Granular Lymphocytic Leukemia". <br> <br> The folder contains: 1) Processed scRNA+TCRab-seq data in a Seurat-folder, including * Object with 11 T-LGLL samples and 6 healthy samples<br> * Object with only hyperexpanded (&gt;= 10 TCRs) T-cells from all T-LGLL samples and 6 healthy samples<br> * Object with only T-LGLL clones from 11 T-LGLL samples<br> * Object with non-leukemic repertoires from 11 T-LGLL samples, 6 healthy samples, 4 CML samples, 4 CLL samples, 2 RCC samples, and 1 NSCLC sample <br> 2) TCRb-seq samples from CD8+ sorted peripheral blood samples from patients with CD8+ T-LGLL Please see manuscript and Github for further details.