Decreased diversity of butyrate-producing bacteria followed by functional adjustment occurs in the microbiome of the simulated proximal colon upon long-term treatment with aspirin. Faecal incubations

We aimed at elucidating how short- and long-term supplementation of aspirin influenced bacterial cell count, community composition and functionality using a dynamic gut model including a mucosal compartment. Faecal incubations were employed to monitor short-term response to clinical concentrations of aspirin and subjects showing opposite fermentation patterns were monitored with the Mucosal Simulator of the Human Intestinal Microbial Ecosystem (M-SHIME) for 6 weeks.