Mechanistic Study on Lobetyolin-Mediated Bile Acid Metabolic Dysregulation and Ileal Injury in Hyperlipidemic Mice Model.

Lobetyolin ameliorates hyperlipidemia by regulating hepatic bile acid synthesis and ileal excretion in mice.Lobetyolin remodels bile acid composition in the ileal contents of hyperlipidemic mice.Lobetyolin alleviates oxidative damage in the ileum of hyperlipidemic mice via the Ref-1/HIF1α pathway.Lobetyolin exerts anti-inflammatory effects by balancing Th1/Th2 and Th17/TGF-β responses in hyperlipidemic mice.Lobetyolin improves intestinal barrier function by upregulating tight junction proteins in hyperlipidemic mice.Lobetyolin-mediated repair of ileal injury in hyperlipidemic mice is associated with bile acid modulation.Lobetyolin may serve as a functional food for preventing hyperlipidemia.