Additional file 1 of Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors
收藏Figshare2021-12-22 更新2026-04-08 收录
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https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Fibroblast_growth_factor_FGF_FGF_receptor_FGFR_and_cyclin_D1_CCND1_DNA_methylation_in_head_and_neck_squamous_cell_carcinomas_is_associated_with_transcriptional_activity_gene_amplification_human_papillomavirus_HPV_status/17359093/1
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Additional file 1: Table S1. DNA methylation analysis of the encoding genes CCND1, FGFR1-4, FGF1-14, and FGF16-23 at single CpG site resolution (840 CpG sites), employing The Cancer Genome Research Atlas (TCGA) HNSCC cohort (N = 530 tumor and N = 50 normal adjacent tissue samples) and HNSCC cell lines (N=40). Single CpG DNA methylation level, spearman’s rank correlation to mRNA expression with regard to human papilloma (HPV) and gene amplification status, and correlation of methylation with sensitivity to the selective FGFR inhibitors PD 173074 and AZD4547 in HNSCC cell lines were included.
提供机构：
Dietrich, Jörn; Gabrielpillai, Jennis; Bao, Yilin; Zarbl, Romina; Schröck, Friederike; Strieth, Sebastian; Dietrich, Dimo
创建时间：
2021-12-22
