LC-MSMS datasets for serum samples

Consistent patterns of variation in the gut microbiota, particularly in the relative abundance, have been identified in the adult human gut. Enterotype, another general measure of the gut microbiota, have been suggested as a valuable approach for categorizing human gut microbiota into distinct clusters. The impact of different enterotypes on human health varies, and the changes induced by moderate-altitude exposure remain unclear. This study conducted an in-depth investigation of the cascade effects triggered by enterotype shifts following moderate-altitude exposure.Using shotgun metagenome sequencing, participants before and after moderate-altitude exposure were classified into two groups: cluster BL (dominated by Blautia) and cluster BA (dominated by Bacteroides). Compared to cluster BL, Cluster BA had lower metabolic diseases associated clinical indices (e.g. lower triglycerides and low-density lipoprotein cholesterol), amino acids, fatty acids and bile acids, but abundant correlations among them than cluster BL,Individuals with baseline BL enterotype switched to BA enterotype after moderate-altitude exposure showed prominent improvement in fasting blood glucose with higher Bacteroides species and L-Glutamine but lower L-Glutamate.