Gene expression profile at single cell level of primary neuronal culture from cortices of C57Bl6 and hTau mice treated with pathogenic brain-derived Tau oligomers

Primary cortical neurons are established tool to study Tau oligomers-mediated toxicity. We used single-cell RNA seq to identify diverisity of gene expression upon Tau oligomers treatment Primary cortical neurons have been isolated from embrionic brains from two mouse models C57 (wt) and hTau and their RNAs analyzed according to the treatement with Tau oligomers