Additional file 1: of Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis

Table S1. Summary of GWAS data. Table S2. SNP based heritability and genomic inflation factor estimated by LDSC. Table S3. Evaluation of genetic correlation between COPD and CVD related metabolic traits. Table S4. Partitioned genetic correlation between COPD and 3 cardiac traits. Table S5. Local genetic covariance analysis between COPD and RHR (only P < 0.01 shown in this table). Table S6. Local genetic coveriance analysis between COPD and HBP (only P < 0.01 shown in this table). Table S7. Local genetic covariance analysis between COPD and CAD. Table S8. Genome-wide significant loci by cross-trait meta-analysis at sentinel SNPs. Table S9. Genome-wide significant loci by cross-trait meta-analysis at sentinel SNPs. Table S10. Genome-wide significant loci by cross-trait meta-analysis at sentinel SNPs. Table S11. Detailed annotation of cross-trait meta-analysis genome-wide significant SNPs. Table S12. Fine-mapping credible set analysis for 21 top loci. Table S13. Fine-mapping credible set analysis for 22 top loci. Table S14. Fine-mapping credible set analysis for 3 top loci. Table S15. Missense variants in 99% credible set. Table S16. Missense variants in 99% credible-set. Table S17. Missense variantsin 99% credible-set. Table S18. GO biological process pathway analysis for COPD and RHR. Table S19. GO biological process pathway analysis for COPD and HBP. Table S20. GO biological process pathway analysis for COPD and CAD. Table S21. Significant overlap transcriptome-wide association analysis results. Table S22. Characterization of trait-specific association for the smoking related. Table S23. Mendelian randomization analysis between COPD and cardiac traits. (XLSX 240 kb)