Results of co-localization/co-clustering of CD3+CD8+ (cytotoxic T-cells) and CD3+ FOXP3+ (regulatory T-cells) using bivariate Ripley’s K for the ROIs and TMAs.

Degree of spatial clustering based on permutation-based estimate of CSR. Models were adjusted for age at diagnosis and stage. The no cytotoxic T-cells and no regulatory T-cells (none) group/category is the reference group. The overall p-value is the joint association of the five categorial variable based on immune abundance and spatial clustering on overall survival.