Selection of interview questions.

Although the Safe Motherhood Initiative is currently a global priority, the implications of maternal self-medication for meeting Safe Motherhood and Sustainable Development Goal 3 objectives in low- and middle-income countries has yet to be addressed. Although local medical doctors are an influential stakeholder group, able to determine health policy, how they view and feel about the problem of antimicrobial self-medication during pregnancy is not well understood. Thus, this study explores physicians’ views and sentiments regarding antibiotic self-medication in pregnant women from a West African country. We used mixed qualitative and quantitative analytic approaches. Semi-structured interviews were conducted with 25 medical doctors working in three tertiary hospitals. Thematic analysis was employed to identify key perspectives, while sentiment analysis was used to determine the emotional tone, based on an open-source pre-trained machine learning model for natural language processing. Several checks for methodological rigour were performed, including reviewing records of over 800 email conversations, and conducting respondent validation. Seven distinct themes emerged depicting views on antimicrobial treatment (e.g., easy availability of antibiotics), patient behaviour (e.g., use of medicinal herbs) and policy guidelines on antibiotics stewardship (lack of clear protocols). The prevailing sentiment portrayed a predominantly neutral demeanour towards antibiotic self-medication during pregnancy (χ2 (1, N = 1484) = 1314.858, p < 0.001), with an unusually high number of neutral labels, compared with positive (z = -36.058, p < 0.001) and negative (z = -36.410, p < 0.001) categories. The results of this investigation can provide useful information for managing antibiotic self-medication in pregnant women from resource-deprived regions where medical doctors are influential stakeholders. Our findings can be used to tailor local Safe motherhood policy initiatives on antimicrobial stewardship during pregnancy such that they address physician’s concerns and sentiments, including insufficient clinical practice guidelines and an ostensible lack of urgency.