RNA-sequencing data of post-mortem brain tissue taken from individuals with SCA3 and controls

Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant inherited ataxia worldwide, caused by a CAG repeat expansion in the Ataxin-3 gene resulting in a polyglutamine (polyQ)-expansion in the corresponding protein. Here we have RNA-sequencing data from the cerebellum of individuals with SCA3 and matched controls.

脊髓小脑性共济失调3型（SCA3）是全球最常见的常染色体显性遗传性共济失调，其由Ataxin-3基因中的CAG重复扩增所致，导致相应蛋白中的多谷氨酰胺（polyQ）扩展。在此，我们提供了SCA3患者及其匹配对照者的小脑RNA测序数据。