Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #7 of 20)
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Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #7 of 20) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-03-08 Release date: 2024-03-06 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
与GTP结合的Gs异源三聚体(GTP-bound Gs heterotrimer)结合的β2肾上腺素能受体(beta-2-adrenergic receptor)的局部优化冷冻电镜(cryoEM)结构,为20个过渡中间体中的第7号。配体描述:(5R,6R)-6-(甲氨基)-5,6,7,8-四氢萘-1,2,5-三醇、β2肾上腺素能受体(beta-2-adrenergic receptor)。作者:帕帕塞吉-斯科特(Papasergi-Scott, M.M.)、斯基尼奥蒂斯(Skiniotis, G.)。提交日期:2023年3月8日。发布日期:2024年3月6日。最后修改日期:2024年11月6日。实验方法:电子显微镜(Electron Microscopy),分辨率3.2埃(Å)。引用文献:G蛋白偶联受体(G protein-coupled receptor, GPCR)激活G蛋白的时间分辨冷冻电镜研究(Time-resolved cryo-EM of G-protein activation by a GPCR),《自然》(Nature),第629卷,2024年



