Sensitivity of the catalytic residue identification methods at different specificity thresholds.

KL is the Kullback-Leibler conservation score, pMI is the proximity averaged mutual information score. pC is the proximity averaged conservation score, KL+pMI is the combined score of KL and pMI, KL+pC is the combined score of KL and pC, and Cls is the Catalytic likeliness score, The sensitivity is determined as an average over the 434 CSA families at the different specificity thresholds. In bold is highlighted the best performing method at each specificity level.