A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice

The circadian clock system regulates a wide range of physiological processes in mammals, and the core circadian clock gene Bmal1 is crucial for maintaining the oscillations of circadian clock system by controlling the rhythmic expression of numerous clock-controlled genes. These data offer a valuable resource for researchers studying the role of BMAL1 in liver physiology and pathology, as well as the broader field of circadian biology. To explore the transcriptional changes associated with Bmal1 deletion in liver tissues, we collected the liver tissues of global and liver-specific Bmal1 knockout mice at two circadian time points (CT2 and CT14), and used them for RNA-seq analysis. Bmal1+/−mice on C57BL/6J background were bred to generate Bmal1+/+ and Bmal1-/- mice . The Bmal1f/f (F) and Alb-Cre mice were bred to generate L-Bmal1−/− (liver- specific Bmal1 knockout, LKO) mice. KO = global Bmal1 knockout LKO = liver-specific Bmal1 knockout F (Bmal1f/f) = the control mice for LKO (liver-specific Bmal1 knockout, Alb-Cre; Bmal1f/f ); These mice (Bmal1f/f) have a floxed Bmal1 genotype but do not express Cre, serving as appropriate controls for the liver-specific knockout.