Transcriptomic profiles of human aortic smooth muscle cell (HASMC) which exposed to M(con) or M(Hb) macrophage supernatant with osteogenic conponents supplementation. Transcriptomic profiles of human aortic smooth muscle cell (HASMC) which exposed to M(con) or M(Hb) macrophage supernatant with osteogenic conponents supplementation

Vasclar calcification (VC) is concomitant with atherosclerosis. CD163+ M(Hb) macrophages at the site of intraplaque hemorrhage of advanced atherosclerosis provoke angiogenesis and microvascular permeability contributing plaque destabilazation. We investigated the role of CD163+ macrophage on the process of VC, and found CD163+ macrohpages inhibit VC through NFκB-induced hyaluronan synthase augmentation and subsequently promote the high-risk plaque development. Overall design: Transcriptomic profiles of human aortic smooth muscle cell (HASMC) which exposed to M(con) or M(Hb) macrophage supernatant with osteogenic conponents supplementation for 6 hours were examined by ClariomTM S microarray.