Genome-wide transcriptome analysis of SARS-CoV-2 positive patients' mucosa, compared with negative controls.

We report the application of genome-wide RNA-sequencing analysis for SARS-CoV-2 positive patients' mucosa. We analyzed the correlation between gene expression levels and viral load (assessed with qPCR) and found a gene signature that might be relevant for diagnosis and treatment of SARS-CoV-2 infection. We performed such analyses in samples with assigned lineage B.1 or B.1.617 (Delta). We compared the expression of these genes in negative patients and observed low abundance, thus confirming their significance. Overall design: mRNA profiles of SARS-CoV-2 positive patients' mucosa and negative controls.