Cryo-EM structure of phophorylated Drs2p-Cdc50p in a PS and ATP-bound E2P state

Cryo-EM structure of phophorylated Drs2p-Cdc50p in a PS and ATP-bound E2P state Descriptor: (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Timcenko, M, Wang, Y, Lyons, J.A, Nissen, P, Lindorff-Larsen, K. Deposit date: 2021-08-10 Release date: 2022-08-24 Last modified: 2026-03-04 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Substrate Transport and Specificity in a Phospholipid Flippase To Be Published冷冻电镜（Cryo-EM）结构：处于磷酸化状态、结合磷脂酰丝氨酸（phosphatidylserine, PS）与腺苷-5'-三磷酸（ATP）的E2P构象的Drs2p-Cdc50p复合物。描述项：(2R)-1-{[(R)-羟基{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-四羟基-4-(膦酰氧基)环己基]氧基}磷酰基]氧基}-3-(十八烷酰氧基)丙-2-基 (5Z,8Z,11Z,14Z)-二十碳-5,8,11,14-四烯酸酯、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖、腺苷-5'-三磷酸……。作者：Timcenko, M、Wang, Y、Lyons, J.A、Nissen, P、Lindorff-Larsen, K。存档日期：2021-08-10；发布日期：2022-08-24；最后修改日期：2026-03-04。实验方法：电子显微镜（分辨率3.1 Å）。引用文献：《磷脂翻转酶的底物转运与特异性》待发表。