Neurotransmitter receptors and ion channels in the somatosensory of C57BL/J6 mice

This dataset contains tables and histograms showing the density, expressed as number of immunoparticles/µm2) of several neurotransmitter receptors subtypes (GABAB receptors and mGlu5 receptors) and ion channel subtypes/subunits (GIRK2 channels, SK2 channels and Cav2.1 channels) along different compartments of the axo-somato-dendritic domains of pyramidal cells in a given cortical layer. We used cutting-edge experimental immunolocalization approaches, the SDS freeze-fracture labelling (SDS-FRL) in the somatosensory cortex of 4 week-old C57BL/J6 mice. The dataset also contains tables showing the spatial relation, expressed as the nearest neighbouring distances in nm, between receptors and effector ion channels to investigate the extent of overlap in different neuronal compartment. Finally, the dataset also contains electron microscopic images of the labelling obtained using specific antibodies for the above mentioned receptors of the different neuronal compartment. Altogether, the data shows the precise subcellular localization of the receptors providing for the first time a map along the 2-dimensional surface of cortical pyramidal cells.