Palladium(0)-Catalyzed Asymmetric C–H Alkenylation for Efficient Synthesis of Planar Chiral Ferrocenes

Pd­(0)-catalyzed intramolecular
C–H alkenylation was achieved
with excellent yields and enantioselectivity for the construction
of planar chiral ferrocenes. It is compatible with a broad range of
substrates and various functional groups. Notably, the enantioselective
and diastereoselective synthesis of planar chiral ferrocenes was realized
by cascade C–H arylation and alkenylation reaction for the
first time. Additionally, the product was easily converted into a N,O-bidentate ligand, showing promising
chiral induction in asymmetric alkynylation of 1-naphthaldehyde.