The Synthesis of Bicyclo[4.2.1]nona-2,4,7-trienes by [6π + 2π]-Cycloaddition of 1‑Substituted 1,3,5-Cycloheptatrienes Catalyzed by Titanium and Cobalt Complexes
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https://figshare.com/articles/dataset/The_Synthesis_of_Bicyclo_4_2_1_nona-2_4_7-trienes_by_6_2_-Cycloaddition_of_1_Substituted_1_3_5-Cycloheptatrienes_Catalyzed_by_Titanium_and_Cobalt_Complexes/8397047
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资源简介：
The
[6π + 2π]-cycloaddition of alkynes to 1-methyl-,
propyl-, benzyl-, and hydroxymethyl-substituted 1,3,5-cycloheptatrienes
in the presence of catalytic systems Ti(acac)2Cl2-Et2AlCl and Co(acac)2(dppe)/Zn/ZnI2 was performed for the first time to give practically valuable bicyclo[4.2.1]nona-2,4,7-trienes
in high yields (72–88%). The structures of the obtained bicyclic
compounds were reliably proved by NMR methods and X-ray diffraction
analysis. The newly synthesized bicycles have been investigated for
their in vitro cytotoxic activity against Jurkat, K562, U937, and
HL60 tumor and normal cell lines and induction of apoptosis.
创建时间：
2019-06-19
