Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation. Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

We systemetically distinguished the effects of each class of sex-biasing factors on transcriptome regulation in liver and adipose tissues with the Four Core Genotype (FCG) mouse model. The results offers a tissue-specific account of the individual contribution of major sex-biasing factors to gene regulation. Overall design: We utilized the Four Core Genotype (FCG) mouse model with or without hormone replacement to distinguish the effects of each class of sex-biasing factors on transcriptome regulation (e.g., gene expression, molecular pathways, gene network organizations, etc.) in liver and adipose tissue.